Esozol

Esomeprazole

Antiulcerant

Indication:

·???????? Treatment of Gastroesophageal Reflux Disease (GERD)

?-Healing of erosive esophagitis

?-Maintenance of healing of erosive esophagitis

?-Symptomatic Gastroesophageal Reflux Disease (GERD)

·???????? Risk reduction of NSAID-associated gastric ulcer

·???????? H. pylori eradication (Triple therapy)

Dosage & Administration:

Recommended adult dosage schedule of Esomeprazole:

?

Indication

Dose

Frequency

Gastroesophageal Reflux Disease (GERD)

Healing of erosive esophagitis

20 mg or 40 mg

Once daily for 4 to 8 weeks*

Maintenance of healing of erosive esophagitis

20 mg

Once daily**

Symptomatic GERD

20 mg

Once daily for 4 weeks ***

Risk Reduction of NSAID- associated gastric ulcer

20 mg or 40 mg

Once daily for up to 6 months**

H. pylori eradication (Triple therapy)

Esomeprazole

20 mg

Twice daily for 10 days

Amoxicillin

1000 mg

Twice daily for 10 days

Clarithromycin

500 mg

Twice daily for 10 days





Paediatric use (12 years and older)

Short term treatment of GERD: 20 mg or 40 mg once daily for up to 8 weeks.

*The majority of patients are healed within 4 to 8 weeks. For patients who do not heal after 4-8 weeks, an additional 4-8 weeks treatment may be considered.

?** Controlled studies did not extend beyond six months.

*** If symptoms do not resolve completely after 4 weeks, an additional 4 weeks of treatment may be considered.

Preparation:

Each delayed release capsule contains enteric coated pellets of Esomeprazole Magnesium Trihydrate BP equivalent to Esomeprazole 20 mg.